PhD position in Pediatric Cancer Epigenetics (FPI funded)


  • Location: Esplugues de Llobregat (Spain)
  • Contract: Contract for Works and Services
  • Working day: Full time
  • Sector: Healthcare
  • Vacancies: 1
  • Discipline: Other

Fundació per a la Recerca Sant Joan de Déu

The Fundació Privada per a la Recerca Sant Joan de Déu is an entity created in 2002 to cover the research activity that is carried out, both in the biomedical and social sphere, at the Maternal and Infantile Hospital of Esplugues, in the Parc Sanitari de Sant Boi de Llobregat and in other centers of the Hospital Order San Juan de Dios - Province of Aragon San Rafael.
 
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Job description

MINECO (PID2020-118241RA-I00)

 

The recently formed Pediatric Cancer Epigenetics group of Dr. Alexandra Avgustinova is recruiting one PhD student to investigate the molecular mechanisms underlying epigenomically-driven tumourigenesis, using Malignant Rhabdoid Tumours (MRTs) as a model. 

 

MRTs are highly malignant and heterogeneous pediatric cancers with abysmal prognosis (5 year survival < 20%). They are characterized by biallelic inactivation of the SWI/SNF subunit SMARCB1, which at the same time represents their only recurrent mutation, making MRTs the best example of epigenetically-driven tumourigenesis. Our larger mission is to identify new clinical intervention nodes for the treatment of MRTs and hence to improve patient welfare and prognosis.

 

The project is multidisciplinary and will involve the use of cell and molecular biology, CRISPR/Cas9, cytometry, microscopy, (epi)genomics and computational biology techniques.

 

 

Requirements

  • Master´s Degree (or equivalent) in biology, life sciences or a related discipline
  • Practical experience in cell and molecular biology techniques
  • Excellent organisation, communication and documentation skills
  • Proficiency in English (oral and written)
  • Strong interest in cancer genomics and epigenomics
  • Collegiality and ability to worth both independently and as part of a team
  • Creativity and critical thinking are encouraged
  • License and practical skills in animal experimentation (FELASA B or comparable) are desirable
Job closed

  • Location: Esplugues de Llobregat (Spain)
  • Contract: Contract for Works and Services
  • Working day: Full time
  • Sector: Healthcare
  • Vacancies: 1
  • Discipline: Other